There is a female predominance. The renal arteries are not exclusively involved and the carotid vessels or other aortic branches are also affected, but less commonly than the renal arteries. The mid- and distal portions of the artery are affected whereas in atheromatous disease it is the proximal portion of the artery or the ostium which is involved. Baloon angioplasty has a 90% success rate with a low restenosis rate (much less than with atheromatous disease). ACE inhibitors are contraindicated in the treatment of hypertension in patients with renal artery stenosis. Non-steroidal anti-inflammatory drugs should be avoided.

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